Toll-Like Receptor 2 Mediates Alveolar Macrophage Response to Pneumocystis murina

Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina.

The innate immune response to Pneumocystis infection is not well understood. In this study, normal C57BL/6 mouse alveolar macrophages were found to respond to Pneumocystis murina organisms through Toll-like receptor 2 (TLR2), leading to the nuclear translocation of NF-kappaB and the production of proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) and chemokine macrophage inflammat...

Antiviral Response Than Toll-Like Receptor Toll-Like Receptor 3 Mediates a More Potent

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.

BACKGROUND Glioblastomas are the most aggressive primary brain tumors in humans. Microglia/brain macrophage accumulation in and around the tumor correlates with malignancy and poor clinical prognosis of these tumors. We have previously shown that microglia promote glioma expansion through upregulation of membrane type 1 matrix metalloprotease (MT1-MMP). This upregulation depends on signaling vi...

Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation.

Apolipoprotein (apo)CIII predicts risk for coronary heart disease. We recently reported that apoCIII directly activates human monocytes. Recent evidence indicates that toll-like receptor (TLR)2 can contribute to atherogenesis through transduction of inflammatory signals. Here, we tested the hypothesis that apoCIII activates human monocytoid THP-1 cells through TLR2. ApoCIII induced the associat...

HIV impairs alveolar macrophage mannose receptor function against Pneumocystis carinii.